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Germline Whole Genome Sequencing
Volta Labs’ instrument streamlines the preparation of high-quality DNA libraries for whole-genome sequencing (WGS), automating labor-intensive steps to improve efficiency, consistency, and throughput. By integrating high-molecular-weight (HMW) DNA extraction with robust library prep workflows, the platform enhances sequencing performance for comprehensive germline variant analysis, de novo genome assembly, and other WGS applications.
Key Benefits
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Reduces hands-on time while ensuring reproducibility in DNA extraction and library prep.
Supports flexible batch sizes, allowing for efficient parallel processing of multiple samples.
Extracts and processes HMW DNA with minimal fragmentation, enabling optimal read lengths for long-read sequencing technologies.
Generates high-quality libraries that yield accurate variant calls and complete genomic coverage.
Application-Specific
Features
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Automates the purification of high-integrity DNA, reducing manual variability and optimizing recovery.
Supports enzymatic fragmentation, ligation, and size selection to create sequencing-ready libraries compatible with multiple platforms.
Prepares SMRTbell libraries for high-fidelity long-read sequencing, ensuring robust performance across various genome sizes and complexities.
Performance
Highlights
High-yield, high-integrity DNA extraction suitable for long-read sequencing.
Low duplication rates and consistent fragment sizing for short-read platforms.
Reliable variant detection across technical replicates, ensuring high confidence in germline analysis.