Targeted Sequencing

Volta Labs’ instrument automates the preparation of high-quality targeted sequencing libraries, reducing errors and increasing throughput for applications such as disease gene panels, exome sequencing, and biomarker discovery. The platform seamlessly integrates hybridization capture and library prep workflows, improving uniformity and reducing sequencing costs.

Key Benefits

High Reproducibility

Minimizes variability across samples, leading to consistent on-target capture rates.

Reduced Hands-On Time

Fully automates hybridization, washes, and amplification steps, streamlining NGS library prep.

Optimized Multiplexing

 Efficiently pools multiple samples without compromising uniformity, reducing probe costs.

Improved Coverage Across GC-Rich Regions

Enhances sequencing depth in challenging genomic regions, improving variant detection sensitivity.

Application-Specific
Features

Automated Hybridization Capture:

Standardizes probe-based target enrichment, eliminating inconsistencies in manual processing.

Library Prep for Hybrid Capture Panels:

Supports a wide range of probe panel sizes, ensuring flexible customization for targeted applications.

Low-Input Requirements:

Enables robust sequencing from limited DNA inputs while maintaining high data quality.

Performance
Highlights

  • Less than 2% sequencing redo rates due to improved reproducibility.

  • Ability to multiplex up to 20 libraries per run, reducing per-sample costs.

  • Accurate detection of low-frequency variants, enhancing sensitivity in clinical and research applications.

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